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What would be a workable hypothesis on the mechanism of how cell detects and responds to RNA polymerase stalling?
In the process of Transcription-coupled Repair, a RNA polymerase is stalled by DNA lesion, and, by an unknown mechanism, various proteins, from that of the XG, CS, and TFIIH group, would be recruited to repair the damaged DNA.
What would be a workable hypothesis that explains, in detail, how a cell would accomplish the recruitment of such proteins when the RNA polymerase is stalled?
Thank you very much.